Allan Spradling (Carnegie Inst. for Science)

Allan Spradling (Carnegie Inst. for Science)

Butler Seminar Series

Event Date/Location

March 8, 2017 - 12:00 pm
Thomas Laboratory 003

Speaker

  • Photo of Dr. Allan Spradling

    Allan Spradling

    Howard Hughes Medical Institute Investigator
    Director of the Department of Embryology
    Carnegie Institution for Science

Topic

Drosophila oogenesis as a model system for understanding differentiation and quiescence

Drosophila germline and follicle development provide unparalleled opportunities to understand fundamental aspects of cellular differentiation and reproduction. We have developed techniques for placing the same reporter at specific genomic sites and using reporter behavior during oogenesis to reveal with single cell resolution when chromatin changes such as Polycomb-mediated repression take effect. We have also been investigating chromatin changes in follicle cell progenitors downstream from their stem cell that are needed to become receptive to the Notch signal that initiates terminal differentiation. Finally, we have found that oocyte mitochondria lose membrane polarity, and disassemble their respiratory complexes in response to changes in insulin pathway signaling in order to prepare for oocyte completion and metabolic quiescence. We have developed a system that allows us to characterize the molecular processes that take place within quiescent oocytes and limit how long they can remain viable.

Audience

Free and open to the university community and the public.

Host

Paul Schedl, Department of Molecular Biology