Princeton University Molecular Biology - Molecular Biology Calendar of Events http://molbio.princeton.edu Thu, 30 Oct 2014 22:43:44 -0400 Joomla! - Open Source Content Management en-gb Vanisha Lakhina (Murphy Lab) http://molbio.princeton.edu/events/all/event/395-lakhina http://molbio.princeton.edu/events/all/event/395-lakhina Location: Schultz Lab, 107 - Princeton
Category: Developmental Biology Colloquia
Date: Fri, Oct 31, 2014 - Fri, Oct 31, 2014
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Developmental Biology Colloquia

Speaker
Vanisha Lakhina
Vanisha Lakhina, Ph.D.
Postdoc, Murphy Lab
Princeton University

Seminar Topic


Insulin/FOXO signaling regulates axonal regeneration  in adult C. elegans

Research lab


http://www.molbio1.princeton.edu/labs/murphy/index.html

Audience

Free and open to the university community and the public


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Developmental Biology Colloquia Mon, 18 Aug 2014 15:09:18 -0400
Olga Vitek (Purdue) http://molbio.princeton.edu/events/all/event/384-vitek http://molbio.princeton.edu/events/all/event/384-vitek Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Nov 03, 2014 - Mon, Nov 03, 2014
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Statistical methods and tools for mass spectrometry-based proteomics

Mass spectrometry-based proteomics studies proteins in complex biological mixtures. Tremendous progress in experimental workflows and instruments now enables investigations that are quantitative, accurate and high-throughput. At the same time, the structure of stochastic variation and uncertainty in proteomic experiments presents interesting methodological challenges of statistical nature.

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Quantitative & Computional Biology Thu, 25 Sep 2014 10:27:14 -0400
Ahmet Yildiz (UC, Berkeley) http://molbio.princeton.edu/events/all/event/357-yildiz http://molbio.princeton.edu/events/all/event/357-yildiz Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Nov 05, 2014 - Wed, Nov 05, 2014
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Butler Seminar Series

Speaker
Ahmet
Ahmet Yildiz, Ph.D.
University of California, Berkeley

Ahmet Yildiz is Assistant Professor of Biochemistry, Biophysics and Structural Biology at the University of California, Berkeley.  Yildiz laboratory combines molecular biology and biophysical techniques to understand mechanisms that underlie the cellular organization and motility. Single molecule imaging enables direct observation of molecular motions, time courses of reactions and heterogeneity in subpopulations of the proteins. One major focus is to understand how microtubule motors work individually and how their interaction play a key role in intracellular transport and organismal motility. We are also using superresolution imaging techniques to visualize high order structures of telomeric DNA in human cells.

Seminar Topic

 
The Mechanism of Cytoplasmic Dynein Motility

Cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation tasks along microtubule filaments. The mechanism of dynein motility remains unclear, due to its large size (2.6 MDa) and the complexity of its structure. Using a variety of single molecule imaging and manipulation methods, we observed that dynein heads move independently along the MT, in contrast to hand over hand movement of kinesins and myosin. Dynein utilizes two distinct stepping mechanisms depending on the separation between the heads. Nucleotide-dependent release is inhibited by the tension on the linker at high separations. The two heads of a dynein dimer share the load to resist larger opposing forces. The minus-end directionality is determined by the asymmetric binding and release properties of the microtubule binding interface. Reversing the asymmetry of the microtubule binding domain resulted in plus-end directed motility. Finally, the AAA3 site is a secondary site of ATP hydrolysis that acts as a molecular switch to repurpose dynein for cargo transporting and microtubule anchor functions. On the basis of these measurements, we propose a quantitative model that describes the basis of dynein processivity, directionality and force generation.
 

Research lab


http://research.physics.berkeley.edu/yildiz/
 
 

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Frank Tong (Vanderbilt) http://molbio.princeton.edu/events/all/event/377-tong http://molbio.princeton.edu/events/all/event/377-tong Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Nov 06, 2014 - Thu, Nov 06, 2014
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Neuroscience Seminar Series

Speaker
tong
Frank Tong, Ph.D.
Vanderbilt University

Seminar Topic

 
TBA
 

research Lab


http://www.psy.vanderbilt.edu/tonglab/web/Home.html

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Victor Varner (Nelson Lab) http://molbio.princeton.edu/events/all/event/397-varner http://molbio.princeton.edu/events/all/event/397-varner Location: Schultz Lab, 107 - Princeton
Category: Developmental Biology Colloquia
Date: Fri, Nov 07, 2014 - Fri, Nov 07, 2014
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Developmental Biology Colloquia

Speaker
Victor
Victor Varner, Ph.D.
Postdoc, Nelson Lab
Princeton University

Seminar Topic


Mechanical control of airway branching morphogenesis in the developing mouse lung

Research lab


http://www.princeton.edu/~cmngroup

Audience

Free and open to the university community and the public


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Developmental Biology Colloquia Mon, 18 Aug 2014 15:09:18 -0400
Michael Elbaum (Weizzman) http://molbio.princeton.edu/events/all/event/385-elbaum http://molbio.princeton.edu/events/all/event/385-elbaum Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Nov 10, 2014 - Mon, Nov 10, 2014
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Quantitative & Computional Biology Thu, 25 Sep 2014 10:27:14 -0400
Steven Leach (Memorial Sloan Kettering Cancer Center) http://molbio.princeton.edu/events/all/event/358-leach http://molbio.princeton.edu/events/all/event/358-leach Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Nov 12, 2014 - Wed, Nov 12, 2014
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MolBio Seminar Series

Speaker
Steven Leach
Steven Leach, M.D.
Memorial Sloan Kettering Cancer Center

Steven Leach is the David M. Rubenstein Chair and Director of the Rubenstein Center for Pancreatic Cancer Research at Memorial Sloan Kettering Cancer Center.  Prior to this, he served as the Paul K. Neumann Professor in Pancreatic Cancer at Johns Hopkins, where he was also Professor of Surgery, Oncology and Cell Biology.  Dr. Leach received his bachelor’s degree with high honors in Biology from Princeton University, where he currently serves as a member of the Board of Trustees.  He then completed medical school at Emory University, and clinical training at Yale and M.D. Anderson.  While at Yale, he pursued additional postdoctoral training in Cell Biology under the supervision of Fred Gorelick. Dr. Leach’s lab has a long track record of research productivity in the field of pancreatic tumor biology.  Dr. Leach’s group is credited with discovery of abnormal Notch pathway activation as an important driver of pancreatic tumorigenesis, development of the first zebrafish model of pancreatic cancer, identification of adult acinar cells as effective cells of origin for the initiation of pancreatic “ductal” neoplasia, and the recent identification of a hematopoietic-to-epithelial IL-17 signaling axis required for pancreatic cancer initiation. Together with additional studies of pancreatic developmental biology and pancreatic epithelial plasticity, work from the Leach Lab has contributed significantly to our understanding of early pancreatic cancer.

Seminar Topic

 
Learning about human pancreatic cancer from mouse and zebrafish embryos

By 2020, pancreatic cancer is slated to become the country’s second leading cause of cancer death.  However, the biology underlying pancreatic cancer initiation and progression remains poorly understood.  Using principles and techniques emanating from our studies of pancreatic development in both mouse and zebrafish, we have been able to gain important new insights into mechanisms of cellular plasticity underlying pancreatic cancer initiation, as well as additional signaling pathways required for pancreatic cancer progression. 
 

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Rachel Kadzik (UPenn) http://molbio.princeton.edu/events/all/event/398-kadzik http://molbio.princeton.edu/events/all/event/398-kadzik Location: Schultz Lab, 107 - Princeton
Category: Developmental Biology Colloquia
Date: Fri, Nov 14, 2014 - Fri, Nov 14, 2014
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Developmental Biology Colloquia

Speaker
Rachel
Rachel Kadzik
UPenn

Seminar Topic


TBA

Research lab


TBA

Audience

Free and open to the university community and the public


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Developmental Biology Colloquia Mon, 18 Aug 2014 15:09:18 -0400
Tanja Kortemme (UCSF) http://molbio.princeton.edu/events/all/event/386-kortemme http://molbio.princeton.edu/events/all/event/386-kortemme Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Nov 17, 2014 - Mon, Nov 17, 2014
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Quantitative & Computional Biology Thu, 25 Sep 2014 10:27:14 -0400
Mo Weng (Wieschaus Lab) http://molbio.princeton.edu/events/all/event/399-weng http://molbio.princeton.edu/events/all/event/399-weng Location: Schultz Lab, 107 - Princeton
Category: Developmental Biology Colloquia
Date: Fri, Nov 21, 2014 - Fri, Nov 21, 2014
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Developmental Biology Colloquia

Speaker
Mo Weng, Ph.D.
Postdoc, Wieschaus Lab
Princeton University

Seminar Topic


  Mechanosensitive remodeling of adherens junctions

Research lab


http://molbio.princeton.edu/labs/wieschaus

Audience

Free and open to the university community and the public


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Developmental Biology Colloquia Mon, 18 Aug 2014 15:09:18 -0400
John Murray (Penn) http://molbio.princeton.edu/events/all/event/387-murray http://molbio.princeton.edu/events/all/event/387-murray Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Nov 24, 2014 - Mon, Nov 24, 2014
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Quantitative & Computional Biology Thu, 25 Sep 2014 10:27:14 -0400
John Wikswo (Vanderbilt) http://molbio.princeton.edu/events/all/event/388-wikswo http://molbio.princeton.edu/events/all/event/388-wikswo Location: Carl Icahn Lab, 101 - Princeton
Category: Quantitative & Computional Biology
Date: Mon, Dec 01, 2014 - Mon, Dec 01, 2014
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Quantitative & Computional Biology Thu, 25 Sep 2014 10:27:14 -0400
Frank Sicheri (U of Toronto) http://molbio.princeton.edu/events/all/event/360-sicheri http://molbio.princeton.edu/events/all/event/360-sicheri Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Dec 03, 2014 - Wed, Dec 03, 2014
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Butler Seminar Series

Speaker
sicheri
Frank Sicheri, Ph.D.
University of Toronto

Dr. Frank Sicheri is a Professor in the Biochemistry at the University of Toronto. He received his Ph.D. from McMaster University in 1994.  His lab's research is directed at understanding protein kinase regulation with a focus towards the underlying structural mechanisms that imparts specificity to signaling function. Using x-ray crystallography, we seek to uncover the structural basis for catalytic switching, substrate recognition and down-stream phospho-regulatory mechanisms. In addition, the Sicheri lab is interested in uncovering the structure and function of novel effectors that impact on protein kinase function. These efforts have led our lab into the area of ubiquitin directed proteolysis. The lab's long-term goal is to make use of what they learn to develop drugs to treat human disease.

Seminar Topic

 
TBA
 

Research lab


http://www.mshri.on.ca/sicheri 

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Nachum Ulanovsky (Wiezmann Institute of Science) http://molbio.princeton.edu/events/all/event/401-ulanovsky http://molbio.princeton.edu/events/all/event/401-ulanovsky Location: PNI, Room A32 -
Category: Neuroscience Seminar Series
Date: Thu, Dec 04, 2014 - Thu, Dec 04, 2014
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Neuroscience Seminar Series

Speaker
Nachum Ulanovsky
Nachum Ulanovsky, Ph.D.
Weizmann Institute of Science

Seminar Topic

 
TBA
 

faculty Profile


http://wws.weizmann.ac.il/neurobiology/labs/ulanovsky/laboratory-nachum-ulanovsky

Audience

Free and open to the university community and the public


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Neuroscience Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Roshan Jain (UPenn) http://molbio.princeton.edu/events/all/event/400-jain http://molbio.princeton.edu/events/all/event/400-jain Location: Schultz Lab, 107 - Princeton
Category: Developmental Biology Colloquia
Date: Fri, Dec 05, 2014 - Fri, Dec 05, 2014
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Developmental Biology Colloquia

Speaker
 
Roshan Jain, Ph.D.
UPenn

 

Seminar Topic


TBA

Research lab


Granato Lab (UPenn) - http://www.med.upenn.edu/granato/index.shtml

Audience

Free and open to the university community and the public


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Developmental Biology Colloquia Mon, 18 Aug 2014 15:09:18 -0400
Mansun Law (Scripps) http://molbio.princeton.edu/events/all/event/361-law http://molbio.princeton.edu/events/all/event/361-law Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Jan 21, 2015 - Wed, Jan 21, 2015
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Bulter Seminar Series

Speaker
law
Mansun Law, Ph.D.
The Scripps Research Institute

Dr. Mansun Law is Associate Professor of Immunology and Microbial Science at The Scripps Research Institute. He received his Ph.D. in Virology from the University of Oxford in 2001.  His lab's research focuses on challenges in understanding and generating protective antibodies to highly variable human viruses.

Seminar Topic

 
TBA
 

Research lab


http://www.scripps.edu/law

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Melissa Moore (HHMI/UMass Medical School) http://molbio.princeton.edu/events/all/event/362-moore http://molbio.princeton.edu/events/all/event/362-moore Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Jan 28, 2015 - Wed, Jan 28, 2015
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Butler Seminar Series

Speaker
Melissa Moore
Melissa J. Moore, Ph.D.
University of Massachusetts Medical School

Dr. Moore is Professor and HHMI Investigator of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School.  She received her B.S. degree in chemistry and biology from the College of William and Mary and her Ph.D. degree in biological chemistry from the Massachusetts Institute of Technology. She began working on RNA metabolism during her postdoctoral training with Phillip Sharp at MIT. Dr. Moore's honors include a Searle Scholars Award, a David and Lucile Packard fellowship, and the 2011 ASBMB William C. Rose Award. Research in her laboratory encompasses a broad array of post-transcriptional gene regulatory mechanisms involving RNA and RNA-protein complexes. Their research centers on pre-mRNA processing and large RNA-protein (RNP) complexes.  We study their basic structures and functions as well as their contributions to human disease.  Current areas of investigation include: (1) single molecule analysis of spliceosome assembly; (2) messenger RNP (mRNP) structure and function; (3) RNP egress by nuclear envelope budding; and (4) development of novel therapeutic approaches targeting RNA-based processes.  Enabling these studies, our research spans the disciplines of cell and molecular biology, biochemistry, chemical biology, biophysics and bioinformatics.

Seminar Topic

 
TBA
 

Research lab


http://labs.umassmed.edu/moorelab/Moore_Lab_Website/home.html

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Joseph Mougous (U Washington) http://molbio.princeton.edu/events/all/event/363-mougous http://molbio.princeton.edu/events/all/event/363-mougous Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 04, 2015 - Wed, Feb 04, 2015
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Butler Seminar Series

Speaker
mougous
Joseph Mougous, Ph.D.
University of Washington

Dr. Moore is Associate Professor of Microbiology at the University of Washington. Dr. Mougous performed his graduate studies at the University of California at Berkeley in the laboratory of Dr. Carolyn Bertozzi. His thesis focused on the biosynthesis and role in virulence of sulfated glycolipids produced by Mycobacterium tuberculosis. As a postdoctoral fellow in the laboratory of Dr. John Mekalanos at Harvard Medical School, Dr. Mougous studied protein secretion in Pseudomonas aeruginosa.

A major focus of the Mougous lab is to understand, from both mechanistic and functional perspectives, the type VI protein secretion system (T6SS). This pathway, which is present in hundreds of Gram-negative bacteria, is remarkable in that it can target its substrates–some of which are toxins–to eukaryotic or prokaryotic cells. Current projects in our lab aim to identify novel T6SS substrates and characterize their mechanism-of-action, develop a structure-function model for the T6SS, define the steps leading to activation of the system, and to investigate the impact of the system on bacterial pathogenesis and microbial ecology. The lab employs a diverse toolkit that ranges from animal models of disease to protein crystallography.

Seminar Topic

 
TBA
 

Research lab


http://faculty.washington.edu/mougous

Audience

Free and open to the university community and the public

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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Sreekanth Chalasani (UC, San Diego) http://molbio.princeton.edu/events/all/event/364-chalasani http://molbio.princeton.edu/events/all/event/364-chalasani Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 11, 2015 - Wed, Feb 11, 2015
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Butler Seminar Series

Speaker
chalasani
Sreekanth Chalasani, Ph.D.
University of California, San Diego
Salk Institute for Biological Studies 

Dr. Sreekanth Chalasani is Assistant Professor of Molecular Neurobiology at the Salk Institute for Biological Studies, University of California, San Diego.  Dr. Chalasani received his B.S. from Osmania University, India and his Ph.D. from the University of Pennsylvania.   His lab's research focuses on how neural circuits decode environmental changes and drive behaviors. The lab uses the nematode, C. elegans and zebrafish as models to study brain functions.

Seminar Topic

 
TBA
 

Research lab


http://www.salk.edu/labs/chalasani

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400
Oliver Hobert (Columbia) http://molbio.princeton.edu/events/all/event/365-hobert http://molbio.princeton.edu/events/all/event/365-hobert Location: Lewis Thomas Lab, 003 - Princeton
Category: Butler Seminar Series
Date: Wed, Feb 18, 2015 - Wed, Feb 18, 2015
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Butler Seminar Series

Speaker
Hobert-345x239 0
Oliver Hobert, Ph.D.
Columbia University Medical Center

Oliver Hobert is professor of biochemistry and molecular biophysics at Columbia University.  Dr. Hobert received his Ph.D. from Max Planck Institute for Biochemistry. The main focus of his laboratory is to understand the molecular mechanisms that generate the astounding diversity of cell types in a nervous system.

Seminar Topic

 
TBA
 

Research lab


http://hobertlab.org

Audience

Free and open to the university community and the public


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Butler Seminar Series Mon, 18 Aug 2014 15:09:18 -0400