Michael Levine (UC, Berkeley)
The Regulatory Genome in Animal Development and Evolution
Whole-genome comparisons suggest that organismal complexity scales with increasingly sophisticated mechanisms of gene regulation rather than increases in gene number. The genomes of higher animals are riddled with enhancers, with the human genome containing as many as a million enhancers. Thus, a typical gene is embedded in a complex regulatory landscape containing tens or hundreds of enhancers. An important future challenge is to integrate genome technologies with quantitative imaging methods to elucidate the functional organization of the regulatory genome during dynamic cellular processes. I will discuss our first efforts to examine enhancer dynamics in living embryos.
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