Judith Kimble (University of Wisconsin - Madison)
MolBio Seminar Series
Judith Kimble is a Vilas Professor at the University of Wisconsin-Madison and an Investigator in the Howard Hughes Medical Institute. She received her B.A. at University of California-Berkeley, her Ph. D. from University of Colorado-Boulder and did her postdoctoral training at the MRC Laboratory of Molecular Biology in Cambridge, England. She joined the faculty of the Department of Biochemistry at the University of Wisconsin-Madison in 1983, and has been there since. Kimble is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and the American Philosophical Society.
A Model Stem Cell Niche and Its Control of Germline Self-Renewal and Differentiation
My laboratory focuses on the in vivo regulation of stem cell self-renewal and differentiation in the germline tissue of the small nematode C. elegans. In this tissue, Notch signaling from a single-celled mesenchymal niche promotes maintenance of germline stem cells (GSCs) and an RNA regulatory network drives the choice between self-renewal and differentiation. My talk will focus on two broadly important questions. One is how niche signaling regulates stem cells — what are the downstream effectors? The second is how the sperm/oocyte decision is regulated. In the first half of my talk, I will describe our recent discovery of the key effectors of Notch signaling for GSC maintenance. In the second half, I will describe our use of classical genetics, molecular biology, genomics and chemical reprogramming to tackle the elusive sperm/oocyte decision, highlighting its remarkably plasticity, even in adults.
Free and open to the university community and the public