Eric Verdin (University of California, San Francisco)
MolBio Seminar Series
Sirtuins and Mitochondrial Protein Acylation
Three NAD-dependent protein deacylases, SIRT3, SIRT4 and SIRT5, have been identified in mitochondria. I will review the post translational modifications they regulate, acetylation, succinylation and malonylation, and their biological significance under normal and pathological conditions.
Free and open to the university community and the public