Swathi Arur (MD Andersen)

The event will start on: Mon, Nov 18, 2013 | 4:15 pm
Location: Carl Icahn Lab, 101 | Washington Road

Quantitative & Computational Biology


Swathi ArurSwathi Arur
MD Anderson Cancer Center
Work in the Arur Lab utilizes the nematode Caenorahbditis elegans and germ line development to study ERK signaling. A long-term goal of the lab is to understand how active ERK2 controls and co-ordinates multiple different developmental events in one tissue. Downstream to ERK2, the linear RAS-ERK pathway becomes an intricate network of signaling molecules, with at least 30 direct effectors, each of which functions in its own signaling module to govern an ERK-dependent event. Findings have also shown extensive signal-integration and cross-talk of ERK with other signaling pathways, such as the wnt signaling pathway, the chromatin modification machinery, and the miRNA processing cascade.

Determing in a systematic way how each ERK substrate regulates different biological processes during normal development will a) uncover novel functions of each substrate protein in a specific biological process, and b) also allow us to understand the role of phosphorylation on each substrate in both developmental disorders and oncogenesis, where the downstream ERK substrates likely are key drivers of the disease.


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