Scott Holley (Yale University)
MolBio Seminar Series
Dr. Holley is Associate Professor of Molecular, Cellular and Developmental Biology at Yale University. He received his Ph.D. from the University of Chicago working in the lab of Chip Ferguson. He was next a Damon Runyon Cancer Research Foundation Fellow in the lab of Christiane Nüsslein-Volhard at the Max Planck Institute for Developmental Biology in Tübingen, Germany. He joined Yale University as an Assistant Professor in 2002. His current research includes studies of patterning by the segmentation clock, and the biomechanics of somite morphogenesis and body elongation. In these studies, his lab and its collaborators combine in vivo cell biology, embryology, genetics, imaging and systems level data analysis and modeling to elucidate the mechanisms underlying the development of the musculoskeletal axis.
Systems and biomechanical analyses of vertebrate musculoskeletal axis formation
During vertebrate embryogenesis, cell signaling and tissue mechanics couple body elongation to the segmentation of the vertebral column. Perturbation of these processes leads to vertebral defects such as scoliosis. I will first discuss our systems level analysis of the role of regulated cell flow in the elongation of the zebrafish embryo. I will then present our studies of the reciprocal interactions between cells and extracellular matrix protein Fibronectin during body elongation and segmentation. In total, our studies delineate both the in vivo mechanisms controlling extracellular matrix remodeling as well as the role of cell-Fibronectin matrix interactions in defining tissue mechanics during morphogenesis.
Free and open to the university community and the public