Jill Mesirov (Broad Institute)
Quantitative & Computational Biology Seminar Series
Jill Mesirov is associate director and chief informatics officer at the Broad Institute, where she directs Computational Biology and Bioinformatics. The Broad’s Computational Biology and Bioinformatics community includes computational scientists, software engineers, and information technology experts working throughout the institute’s programs and platforms. They share their expertise across a wide range of biological and technological applications. Mesirov is also a member of the David H. Koch Institute for Integrative Cancer Research at MIT and adjunct professor of bioinformatics at Boston University. .
Computational Approaches for Genomic Medicine
The sequencing of the human genome and the development of new methods for acquiring biological data have changed the face of biomedical research. The use of computational approaches takes advantage of the availability of these data to develop new methods with the promise of improved understanding and treatment of disease. Moreover, it is important to deliver practical, accessible software tools to bring these methods to the general biomedical research community.
I will describe some of these approaches that leverage functional data including our recent work integrating high-level clinical and genomic features to stratify pediatric brain tumor patients into groups with high and low risk of relapse after treatment. The approach provides a more accurate and biologically interpretable model than previous models, and highlights possible future drug targets. It represents one of the few such predictors that generalized to a completely independent patient cohort. Finally, I will review the software that makes our methods available to the research community.
Free and open to the university community and the public