professor of molecular biology
Lab (609) 258-8476
Biological modeling; intracellular networks; molecular biophysics
Intracellular networks in bacteria
Bacteria are constantly sensing their environments and adjusting their behavior accordingly. Signaling occurs through networks of proteins and nucleic acids, culminating in changes of gene expression and so changes in the proteome of the cell. We are focused on the architecture of these intracellular networks. What is the relation between network architecture and function? For example, can we understand the selection of architectures in terms of general information-processing concepts such as signal to noise, memory, and adaptation? Even in a single bacterium such as E. coli, there are hundreds of coexisting networks. Our belief is that a deep study of a small number of "model" networks will yield general tools to analyze information processing by cell. It is important to choose these model networks carefully. The network components should be well characterized and the physiological function of the network should be known and subject to quantitative measurement. Probes of the internal dynamics of the network such as fluorescence resonance energy transfer (FRET) or direct imaging of dynamic spatial structure, will be critical in developing and testing quantitative models. It will also be important to choose networks which complement each other well, spanning a broad range of architectures and functions. A preliminary list includes (i) quorum sensing, in which the cell slowly integrates signals from its neighbors to commit to a developmental decision such as invasion of a host, (ii) chemotaxis, which requires adaptation and rapid response to changing chemical concentrations, (iii) cell-division networks, where accuracy and checkpoints are essential, and (iv) metabolic networks which tie together diverse inputs to maintain homeostasis.
Quorum sensing. Bacteria communicate with each other by diffusible chemical signals. These signals allow bacteria to detect their own population density and, at high enough density, to undertake collective activities such a light production or invasion of a host. We collaborate with the group of Professor Bonnie Bassler (our neighbors) to study the signaling pathway in a number of species including the human pathogen Vibrio cholerae. The quorum-sensing pathway in Vibrios has many features, including coincidence detection and signal averaging, designed to assure robust, high-fidelity signal transduction despite fluctuations both in the environment and in internal protein concentrations. Quorum sensing is a model for developmental decisions, in which multiple signals are integrated over time, culminating in commitment to a particular cell fate.
Chemotaxis. Chemotaxis networks in bacteria allow cells to swim toward attractants such as amino acids or sugars, and away from repellents. In the well-studied case of E. coli, cells perform chemotaxis by detecting temporal changes in their chemical environment and transducing this information into a decision to swim straight or change direction (tumble). The chemotaxis system is remarkable for its high sensitivity to small relative changes in chemical concentrations, over a range of up to five orders of magnitude of concentration. The range of sensitivity depends on an adaptation system in which receptors are actively methylated and demethylated at specific modification sites. Adaptation in chemotaxis is both precise, i.e. cells return precisely to the same rate of tumbles, and robust with respect to the stimulus strength and to variations in the levels of chemotaxis proteins. Motivated by the in vivo FRET studies of receptor activity done by Howard Berg and Victor Sourjik at Harvard, we have developed a model for chemotaxis signaling based on mixed clusters of chemotaxis receptors. We continue to collaborate with the experimental group of Professor Victor Sourjik (now at Heidelberg) to understand the remarkable signaling properties of the chemotaxis network.
Cell-division networks. Cell division requires the proper spatial and temporal organization of numerous division proteins. In the bacteria E. coli and B. subtilis, division into equal daughter cells is measured to be accurate to within a few percent. How do these cells recognize their own shapes and engineer accurate division? We study a number of systems involved in cell division in bacteria, including the Min system that helps position the division apparatus at midcell. The Min proteins in E. coli form a spatial oscillator based on a Turing instability. Our modeling results indicate that the Min oscillations can spontaneously orient along the long axis of cells, even in nearly round cells (cocci). We continue to study the Min system, and other systems involved in protein targeting. In addition, we are collaborating with the group of Professor Zemer Gitai (our other neighbors) on cell division in Caulobacter crescentus. In this species, the two daughter cells have distinct cell fates, a sessile stalked cell and a motile swarmer cell, and cell division is reliably unequal, favoring the stalked cell. The asymmetric cell division in Caulobacter is likely to be a source of insight into the mechanisms of spatial organization at work in bacteria.
Metabolism. Metabolism is the central network of all organisms. While the pathways and enzymes of metabolism have been well studied, there are many open questions about how cells respond dynamically to changes in their nutrient environment. We focus on nitrogen metabolism in bacteria as a tractable sub-system for modeling. The metabolic pathways for nitrogen utilization are relatively simple and the regulatory system, while complex, has been well studied. We believe that the nitrogen system contains the essential features, e.g. failsafe regulatory architecture, sophisticated dynamic control, critical for a general understanding of metabolism. Our modeling studies are complemented by experimental work being done at Princeton in the groups of Professors Josh Rabinowitz (mass spectroscopy) and David Botstein (microarray studies of gene expression).
Aquino G, Wingreen NS, Endres RG. (2016) Know the Single-Receptor Sensing Limit? Think Again. J Stat Phys. 2016;162:1353-1364. PMCID: PMC4761375
Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016) Architectural transitions in Vibrio cholerae biofilms at single-cell resolution. Proc Natl Acad Sci U S A. 2016 Mar 1. [Epub ahead of print]
Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Diet-induced extinctions in the gut microbiota compound over generations. Nature. 529(7585):212-5. Pubmed
Wingreen NS, Huang KC. (2015) Physics of intracellular organization in bacteria. Annu Rev Microbiol. 69:361-379. Pubmed
Borenstein DB, Ringel P, Basler M, Wingreen NS. (2015) Established microbial colonies can survive type VI secretion assault. PLoS Comput Biol. 11(10):e1004520. Pubmed
Rutherford ST, Valastyan JS, Taillefumier T, Wingreen NS, Bassler BL. (2015) Comprehensive analysis reveals how single nucleotides contribute to noncoding RNA function in bacterial quorum sensing. Proc Natl Acad Sci U S A. 112(44):E6038-47. Pubmed
Persat A, Nadell CD, ... Bassler BL, Gitai Z, Stone HA. (2015) The mechanical world of bacteria. Cell. 161(5): 988-997. Pubmed
Taillefumier T, Wingreen NS. (2015) Optimal census by quorum sensing. PLoS Comput Biol. 11(5): e1004238. Pubmed
Bitbol AF, Wingreen NS. (2015) Fundamental constraints on the abundances of chemotaxis proteins. Biophys J. 108:1293-305. Pubmed
Wasnik V, Wingreen NS, Mukhopadhyay R. (2015) Modeling curvature-dependent subcellular localization of the small sporulation protein SpoVM in Bacillus subtilis. PLoS One. 10:e0111971. Pubmed
Nadell CD, Drescher K, Wingreen NS, Bassler BL. (2015) Extracellular matrix structure governs invasion resistance in bacterial biofilms. ISME J. 9(8):1700-9. Pubmed
Feng L, Rutherford ST, Papenfort K,...Wingreen NS, Bassler BL. (2015) A qrr noncoding RNA deploys four different regulatory mechanisms to optimize quorum-sensing dynamics. Cell. 2015 160:228-40. Pubmed
Barry RM, Bitbol AF,... Wingreen NS, Kollman JM, Gitai Z. (2014) Large-scale filament formation inhibits the activity of CTP synthetase. Elife. 3: e03638. Pubmed
Haselwandter CA, Wingreen NS. (2014) The role of membrane-mediated interactions in the assembly and architecture of chemoreceptor lattices. PLoS Comput Biol. 10:e1003932. Pubmed
Bassler BL, Wingreen NS. (2014) Working together at the interface of physics and biology. Phys Biol. 11: 053010. Pubmed
Castellana M, Wilson MZ, Xu Y,...Gitai Z, Wingreen NS. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat Biotechnol. 32: 1011-8. Pubmed
Tikhonov M, Leach RW, Wingreen NS. (2014) Interpreting 16S metagenomic data without
Tikhonov M, Leach RW, Wingreen NS. (2014) Interpreting 16S metagenomic data without clustering to achieve sub-OTU resolution. ISME J. 9:68-80. Pubmed
Broedersz CP, Wang X, Meir Y, Loparo JJ, Rudner DZ, Wingreen NS. (2014) Condensation and localization of the partitioning protein ParB on the bacterial chromosome. Proc Natl Acad Sci. 111: 8809-14. Pubmed
Neumann S, Vladimirov N, Krembel AK, Wingreen NS, Sourjik V. (2014) Imprecision of adaptation in Escherichia coli chemotaxis. PLoS One. 9: e84904. Pubmed
Skoge M, Naqvi S, Meir Y, Wingreen NS (2013) Chemical sensing by nonequilibrium cooperative receptors. Phys Rev Lett. 110(24): 248102. Pubmed
Drescher K, Nadell CD, Stone HA, Wingreen NS, Bassler BL. (2013) Solutions to the public goods dilemma in bacterial biofilms. Curr Biol. 24: 50-55. Pubmed
Dwyer RS, Ricci DP, Colwell LJ, Silhavy TJ, Wingreen NS. (2013) Predicting functionally informative mutations in Escherichia coli BamA using evolutionary covariance analysis. Genetics. 195: 443-55. Pubmed
Borenstein DB, Meir Y, Shaevitz JW, Wingreen NS. (2013) Non-local interaction via diffusible resource prevents coexistence of cooperators and cheaters in a lattice model. PLoS One. 8: e63304. Pubmed
Wang S, Wingreen NS. (2013) Cell shape can mediate the spatial organization of the bacterial cytoskeleton. Biophys J. 104: 541-52. PubMed
Cooper RM, Wingreen NS, Cox EC. (2012) An excitable cortex and memory model successfully predicts new pseudopod dynamics. PLoS One. 7: e33528. PubMed
Wang Y, Tu KC, Ong NP, Bassler BL, Wingreen NS. (2011) Protein-level fluctuation correlation at the microcolony level and its application to the Vibrio harveyi quorum-sensing circuit. Biophys J. 100: 3045-53. PubMed
Furchtgott L, Wingreen NS, Huang KC. (2011) Mechanisms for maintaining cell shape in rod-shaped Gram-negative bacteria. Mol Microbiol. 81: 340-53. PubMed
Wyart M, Botstein D, Wingreen NS. (2010) Evaluating gene expression dynamics using pairwise RNA FISH data. PLoS Comput Biol. 6: e1000979. PubMed
Mora T, Wingreen NS. (2010) Limits of sensing temporal concentration changes by single cells. Phys Rev Lett. 104: 248101. PubMed
Goyal S, Yuan J, Chen T, Rabinowitz JD, Wingreen NS. (2010) Achieving optimal growth through product feedback inhibition in metabolism. PLoS Comput Biol. 6: e1000802. PubMed
Ng WL, Wei Y, Perez LJ,...Wingreen NS, Bassler BL. (2010) Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules. Proc Natl Acad Sci. 107: 5575-80. PubMed
Mora T, Yu H, Wingreen NS. (2009) Modeling torque versus speed, shot noise, and rotational diffusion of the bacterial flagellar motor. Phys Rev Lett. 103: 248102. PubMed
Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL. (2010) Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response. Mol Cell. 37: 567-79. PubMed
Zee BM, Levin RS, Xu B, Leroy G, Wingreen NS, Garcia BA. (2009) In vivo residue-specific histone methylation dynamics. J Biol Chem. 285: 3341-50. PubMed
Mehta P, Goyal S, Long T, Bassler BL, Wingreen NS. (2009) Information processing and signal integration in bacterial quorum sensing. Mol Syst Biol. 5: 325. PubMed
Mora T, Yu H, Sowa Y, Wingreen NS. (2009) Steps in the bacterial flagellar motor. PLoS Comput Biol. 5: e1000540. PubMed
Yuan J, Doucette CD, Fowler WU,...Wingreen NS, Rabinowitz JD. (2009) Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol Syst Biol. 5: 302. PubMed
Long T, Tu KC, Wang Y,...Wingreen NS. (2009) Quantifying the integration of quorum-sensing signals with single-cell resolution. PLoS Biol. 7: e68. PubMed
Ndifon W, Wingreen NS, Levin SA. (2009) Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines. Proc Natl Acad Sci. 106: 8701-06. PubMed
Huang KC, Mukhopadhyay R, Wen B, Gitai Z, Wingreen NS. (2008) Cell shape and cell-wall organization in Gram-negative bacteria. Proc Natl Acad Sci. 105: 19282-87. PubMed
Guberman JM, Fay A, Dworkin J, Wingreen NS, Gitai Z. (2008) PSICIC: noise and asymmetry in bacterial division revealed by computational image analysis at sub-pixel resolution. PLoS Comput Biol. 4: e1000233. PubMed
Mehta P, Goyal S, Wingreen NS. (2008) A quantitative comparison of sRNA-based and protein-based gene regulation. Mol Syst Biol. 4: 221. PubMed
Endres RG, Wingreen NS. (2008) Accuracy of direct gradient sensing by single cells. Proc Natl Acad Sci. 105: 15749-54. PubMed
Pompeani AJ, Irgon JJ, Berger MF, Bulyk ML, Wingreen NS, Bassler BL. (2008) The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters. Mol Microbiol. 70: 76-88. PubMed
Swem LR, Swem DL, Wingreen NS, Bassler BL. (2008) Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell. 134: 461-73. PubMed
Endres RG, Oleksiuk O, Hansen CH, Meir Y, Sourjik V, Wingreen NS. (2008) Variable sizes of Escherichia coli chemoreceptor signaling teams. Mol Syst Biol. 4: 211. PubMed
Mehta P, Mukhopadhyay R, Wingreen NS. (2008) Exponential sensitivity of noise-driven switching in genetic networks. Phys Biol. 5: 26005. PubMed
Hansen CH, Endres RG, Wingreen NS. (2008) Chemotaxis in Escherichia coli: a molecular model for robust precise adaptation. PLoS Comput Biol. 4: e1. PubMed
Endres RG, Falke JJ, Wingreen NS. (2007) Chemotaxis receptor complexes: from signaling to assembly. PLoS Comput Biol. 3: e150. PubMed
Goyal S, Wingreen NS. (2007) Growth-induced instability in metabolic networks. Phys Rev Lett. 98: 138105. PubMed
Li JL, Car R, Tang C, Wingreen NS. (2007) Hydrophobic interaction and hydrogen-bond network for a methane pair in liquid water. Proc Natl Acad Sci. 104: 2626-30. PubMed
Weitz JS, Benfey PN, Wingreen NS. (2007) Evolution, interactions, and biological networks. PLoS Biol. 5: e11. PubMed
Wingreen NS, Levin SA. (2006) Cooperation among microorganisms. PLoS Biol. 4: e299. PubMed
Huang KC, Mukhopadhyay R, Wingreen NS. (2006) A curvature-mediated mechanism for localization of lipids to bacterial poles. PLoS Comput Biol. 2: e151. PubMed
Wingreen N, Botstein D. (2006) Back to the future: education for systems-level biologists. Nat Rev Mol Cell Biol. 7: 829-32. PubMed
Endres RG, Wingreen NS. (2006) Precise adaptation in bacterial chemotaxis through "assistance neighborhoods". Proc Natl Acad Sci. 103: 13040-44. PubMed
Endres RG, Wingreen NS. (2006) Weight matrices for protein-DNA binding sites from a single co-crystal structure. Phys Rev E Stat Nonlin Soft Matter Phys. 73: 061921. PubMed
Emberly E, Wingreen NS. (2006) Hourglass model for a protein-based circadian oscillator. Phys Rev Lett. 9: 038303. PubMed
Skoge M, Endres RG, Wingreen NS. (2006) Receptor-receptor coupling in bacterial chemotaxis: evidence for strongly coupled clusters. Biophys J. 90: 4317-26. PubMed
Keymer JE, Endres RG, Skoge M, Meir Y, Wingreen NS. (2006) Chemosensing in Escherichia coli: two regimes of two-state receptors. Proc Natl Acad Sci. 103: 1786-91. PubMed
Li JL, Chun J, Wingreen NS, Car R, Aksay IA, Saville DA. (2005) Use of dielectric functions in the theory of dispersion forces. Phys Rev B. 71: 235412.
Kruus E, Thumfort P, Tang C, Wingreen NS. (2005) Gibbs sampling and helix-cap motifs. Nucleic Acids Res. 33: 5343-53. PubMed
Kloster M, Tang C, Wingreen NS. (2004) Finding regulatory modules through large-scale gene-expression data analysis. Bioinformatics. 21: 1172-79. PubMed
Huang KC, Wingreen NS. (2004) Min-protein oscillations in round bacteria. Phys Biol. 1: 229-35. PubMed
Kulkarni RV, Huang KC, Kloster M, Wingreen NS. (2004) Pattern formation within Escherichia coli: diffusion, membrane attachment, and self-interaction of MinD molecules. Phys Rev Lett. 93: 228103. PubMed
Zhang N, Zeng C, Wingreen NS. (2004) Fast accurate evaluation of protein solvent exposure. Proteins. 57: 565-76. PubMed
Endres RG, Schulthess TC, Wingreen NS. (2004) Toward an atomistic model for predicting transcription-factor binding sites. Proteins. 57: 262-68. PubMed
Wingreen NS. (2004) Physics. Quantum many-body effects in a single-electron transistor. Science. 304: 1258-59. PubMed
Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, Bassler BL. (2004) The small RNA chaperone Hfq and multiple small RNAs control Quorum Sensing in Vibrio harveyi and Vibrio cholerae. Cell. 118: 69-82. PubMed
Emberly EG, Mukhopadhyay R, Tang C, Wingreen NS. (2004) Flexibility of beta-sheets: principal component analysis of database protein structures. Proteins. 55: 91-98. PubMed
Huang KC, Meir Y, Wingreen NS. (2003) Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones. Proc Natl Acad Sci. 100: 12724-28. PubMed
Mukhopadhyay R, Emberly E, Wingreen NS, Tang C. (2003) Statistical mechanics of RNA folding: Importance of alphabet size. Physical Review E. 68: 041904. PubMed
Wingreen NS, Miller J, Cox EC. (2003) Scaling of mutational effects in models for pleiotropy. Genetics. 164: 1221-28. PubMed
Emberly E, Mukhopadhyay R, Wingreen NS, Tang C. (2003) Flexibility of alpha-helices: Results of a statistical analysis of database protein structures. J Mol Biol. 327: 229-37. PubMed
Mok KC, Wingreen NS, Bassler BL. (2003) Vibrio harveyi quorum sensing: A coincidence detector for two autoinducers controls gene expression. EMBO J. 22: 870-81. PubMed
Hirose K, Meir Y, Wingreen NS. (2003) Local moment formation in quantum point contacts. Phys Rev Lett. 90: 026804. PubMed
Emberly EG, Wingreen NS, Tang C. (2002) Designability of alpha-helical proteins. Proc Natl Acad Sci. 99: 11163-68. PubMed
Li H, Tang C, Wingreen NS. (2002) Designability of protein structures: a lattice-model study using the Miyazawa-Jernigan matrix. Proteins 49: 403-12. PubMed
Miller J, Zeng C, Wingreen NS, Tang C. (2002) Emergence of highly designable protein-backbone conformations in an off-lattice model. Proteins. 47: 506-12. PubMed
Emberly EG, Miller J, Zeng C, Wingreen NS, Tang C. (2002) Identifying proteins of high designability via surface-exposure patterns. Proteins. 47: 295-304. PubMed
Meir Y, Hirose K, Wingreen NS. (2002) Kondo model for the "0.7 anomaly" in transport through a quantum point contact. Phys Rev Lett. 89: 196802. PubMed
Cronenwett SM, Lynch HJ, Goldhaber-Gordon D,...Wingreen NS, Umansky V. (2002) Low-temperature fate of the 0.7 structure in a point contact: a Kondo-like correlated state in an open system. Phys Rev Lett. 88: 226805. PubMed
Helling R, Li H, Melin R, Miller J, Wingreen N, Zeng C, Tang C. (2002) The designability of protein structures. J Mol Graph Model. 19: 157-67. PubMed
Wingreen NS. (2001) The Kondo effect in novel systems. Materials Sci Eng B. 84: 22-25.
Madhavan V, Chen W, Jamneala T, Crommie MF, Wingreen NS. (2001) Local spectroscopy of a Kondo impurity: Co on Au(111). Phys Rev B. 64: 165412.
Grupp DE, Zhang T, Dolan GJ, Wingreen NS. (2001) Dynamical offset charges in single-electron transistors. Phys Rev Lett. 87: 186805.
Wang T, Miller J, Tang C, Wingreen NS, Dill KA. (2000) Symmetry and designability for lattice protein models. J Chem Phys. 113: 8329-36.
Nordlander P, Wingreen NS, Meir Y, Langreth DC. (2000) Kondo physics in the single electron transistor with ac driving. Phys Rev B. 61: 2146-50.
Melin R, Li H, Wingreen NS, Tang C. (1999) Designability, thermodynamic stability, and dynamics in protein folding: A lattice model study. J Chem Phys. 1110: 1252-62.
Hirose K, Wingreen NS. (1999) Spin-density-functional theory of circular and elliptical quantum dots. Phys Rev B. 59: 4604-07.
Nordlander P, Pustilnik M, Meir Y, Wingreen NS, Langreth DC. (1999) How long does it take for the Kondo effect to develop? Phys Rev Lett. 83: 808-11.
Smolyarenko IE, Wingreen NS. (1999) Kondo effect in systems with spin disorder. Phys Rev B. 60: 9675-89.
Hirose K, Wingreen NS. (1999) Electronic structure calculations of quantum dots. NEC Res Devel. 40: 419-23.
Heide C, Elliott RJ, Wingreen NS. (1999) Spin-polarized tunnel current in magnetic-layer systems and its relation to the interlayer exchange interaction. Phys Rev B. 59: 4287-304.
Jauho P, Wingreen NS. (1998) Theory of phase-sensitive measurement of photon-assisted tunneling through a quantum dot. Phys Rev B. 58: 9619-22.
Barkai N, Rose MD, Wingreen NS. (1998) Protease helps yeast find mating partners. Nature. 396: 422-23. PubMed
Madhavan VV, Chen W, Jamneala T, Crommie MF, Wingreen NS. (1998) Tunneling into a single magnetic atom: spectroscopic evidence of the kondo resonance. Science. 280: 567-69. PubMed
Li H, Tang C, Wingreen NS. (1998) Are protein folds atypical? Proc Natl Acad Sci. 95: 4987-90. PubMed
Aleiner L, Wingreen NS, Meir Y. (1997) Dephasing and the orthogonality catastrophe in tunneling through a quantum dot: The "Which Path?" interferometer. Phys Rev Lett. 79: 3740-43.
Li H, Tang, Wingreen NS. (1997) Nature of driving force for protein folding: A result from analyzing the statistical potential. Phys Rev Lett. 79: 765-68.
Wingreen NS, Stafford CA. (1997) Quantum-dot cascade laser: Proposal for an ultralow-threshold semiconductor laser. IEEE J Quantum Electron. 33: 1170-73.
Agam O, Wingreen NS, Altshuler B, Ralph DC, Tinkham M. (1997) Chaos, interactions, and nonequilibrium effects in the tunneling resonance spectra of ultrasmall metallic particles. Phys Rev Lett. 78: 1956-59.
Yacoby A, Stormer HL, Wingreen NS, Pfeiffer LN, Baldwin KW, West KW. (1996) Nonuniversal Conductance Quantization in Quantum Wires. Phys Rev Lett. 77: 4612-15. PubMed
Schwabe NF, Elliott RJ, Wingreen NS. (1996) The Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction across a tunneling junction out of equilibrium. Phys Rev B. 54: 12953-68. PubMed
Sivan N, Wingreen NS. (1996) Single-impurity Anderson model out of equilibrium. Phys Rev B Condens Matter. 54: 11622-29. PubMed
Li H, Helling R, Tang C, Wingreen N. (1996) Emergence of preferred structures in a simple model of protein folding. Science. 273: 666-69. PubMed
Stafford CA, Wingreen NS. (1996) Resonant photon-assisted tunneling through a double quantum dot: An electron pump from spatial Rabi oscillations. Phys Rev Lett. 76: 1916-19. PubMed
Wingreen NS, Altshuler BL, Meir Y. (1995) Comment on "2-channel Kondo scaling in conductance signals from 2-level tunneling systems". Phys Rev Lett. 75: 769. PubMed
Meir Y, Wingreen NS. (1995) Spin-orbit scattering and the Kondo effect. Phys Rev B Condens Matter. 50: 4947-50. PubMed
Jauho AP, Wingreen NS, Meir Y. (1994) Time-dependent transport in interacting and noninteracting resonant-tunneling systems. Phys Rev B Condens Matter. 50: 5528-44. PubMed
Wingreen NS, Meir Y. (1994) Anderson model out of equilibrium: Noncrossing-approximation approach to transport through a quantum dot. Phys Rev B Condens Matter. 49: 11040-52. PubMed
Lee M, Wingreen NS, Solin SA, Wolff PA. (1994) Giant growth axis longitudinal magnetoresistance from in-plane conduction in semiconductor superlattices. Solid State Comm. 89: 687-91.
Middleton AA, Wingreen NS. (1993) Collective transport in arrays of small metallic dots. Phys Rev Lett. 71: 3198-201. PubMed
Kinaret JM, Wingreen NS. (1993) Coulomb blockade and partially transparent tunneling barriers in the quantum Hall regime. Phys Rev B Condens Matter. 48: 11113-19. PubMed
Wingreen NS, Jauho AP, Meir Y. (1993) Time-dependent transport through a mesoscopic structure. Phys Rev B Condens Matter 48: 8487-8490. PubMed
McEuen PL, Wingreen NS, Foxman EB,...Meir Y. (1993) Coulomb interactions and energy-level spectrum of a small electron gas. Physica B. 189: 70-79.
Foxman EB, McEuen PL, Meirav U, Wingreen NS,...Wind SJ. (1993) Effects of quantum levels on transport through a Coulomb island. Phys Rev B Condens Matter. 47: 10020-23. PubMed
Meir Y, Wingreen NS, Lee PA. (1993). Low-temperature transport through a quantum dot: The Anderson model out of equilibrium. Phys Rev Lett. 70: 2601-04. PubMed
Kinaret JM, Meir Y, Wingreen NS, Lee P, Wen XG. (1992) Conductance through a quantum dot in the fractional quantum Hall regime. Phys Rev B Condens Matter. 45: 9489-92. PubMed
Kinaret JM, Meir Y, Wingreen NS, Lee PA, Wen XG. (1992) Many-body coherence effects in conduction through a quantum dot in the fractional quantum Hall regime. Phys Rev B Condens Matter. 46: 4681-92. PubMed
Meir Y, Wingreen NS. (1992) Landauer formula for the current through an interacting electron region. Phys Rev Lett. 68: 2512-15. PubMed
McEuen PL, Foxman EB, Kinaret J,...Wingreen NS, Wind SJ. (1992) Self-consistent addition spectrum of a Coulomb island in the quantum Hall regime. Phys Rev B Condens Matter. 45: 11419-22. PubMed
McEuen PL, Foxman EB, Meirav U, Kastner MA, Meir Y, Wingreen NS, Wind SJ (1991) Transport spectroscopy of a Coulomb island in the quantum Hall regime. Phys Rev Lett 66: 1926-1929. PubMed
Meir Y, Wingreen NS, Entin-Wohlman O, Altshuler BL. (1991) Spin-orbit scattering for localized electrons: Absence of negative magnetoconductance. Phys Rev Lett. 66: 1517-20. PubMed
Meir Y, Wingreen NS, Lee PA. (1991) Transport through a strongly interacting electron system: Theory of periodic conductance oscillations. Phys Rev Lett. 66: 3048-51. PubMed
Wingreen NS. (1990) Rectification by resonant tunneling diodes. Appl Phys Lett. 56: 253-55.
Wingreen NS, Jacobsen KW, Wilkins JW. (1989) Inelastic scattering in resonant tunneling. Phys Rev B. 40: 11834-50.
Wingreen NS, Combescot M. (1989) Electron-electron scattering: Collision integral and relaxation rate. Phys Rev B Condens Matter. 40: 3191-96. PubMed
Wingreen NS, Combescot M. (1989) Ohm's Law for hot carriers: the role of carrier-carrier scattering at high fields. Solid State Comm. 70: 185-89.
Wingreen NS, Jacobsen KW, Wilkins JW. (1988) Resonant tunneling with electron-phonon interaction: An exactly solvable model. Phys Rev Lett. 61: 1396-99. PubMed
Wingreen NS, Stanton CJ, Wilkins JW. (1986) Electron-electron scattering in nondegenerate semiconductors: Driving the anisotropic distribution toward a displaced Maxwellian. Phys Rev Lett. 57: 1084-87. PubMed