Alvaro Sagasti (University of California, Los Angeles)

The event will start on: Wed, Oct 16, 2013 | 12:00 pm
Location: Lewis Thomas Lab, 003 | Washington Road

MolBio Seminar Series

Speaker

sagastiAlvaro Sagasti
University of California, Los Angeles

Dr. Sagasti is an Associate Professor in the Department of Molecular, Cell and Developmental Biology at UCLA. He received his BA from Williams College and his Ph.D. from UCSF, where he worked with Cori Bargmann studying olfactory sensory neuron differentiation in C. elegans. Dr. Sagasti began his research on zebrafish somatosensory neurons as a post-doctoral fellow in Alex Schier’s lab at the Skirball Institute at NYU. He set up his lab at UCLA in 2005, where his group studies the development, regeneration and degeneration of peripheral sensory axons that detect touch stimuli. Recently his group has focused on investigating the reciprocal molecular interactions between axon endings and the skin cells they innervate.

 

Seminar Topic

Reciprocal interactions between skin cells and neurons regulate morphogenesis and maintenance of touch sensory axons

The axons of somatosensory neurons innervate the skin early in development to detect touch. To function properly these axons must navigate to and within the skin epithelium, where they adopt a complex three-dimensional architecture. The skin is often thought of as an inert substrate for developing sensory axons, but our recent work has revealed active roles for skin cells in the development and maintenance of sensory axon endings, reminiscent of functions carried out be glial cells in other parts of the nervous system. Specifically, our findings suggest that 1) skin cells produce heparan sulfate proteoglycans that attract sensory axons to the periphery, 2) embryonic sensory axons induce dramatic morphological changes in skin cells, causing them to tightly ensheath innervating axons, and 3) skin cells phagocytose axon debris during developmental pruning and after injury. Together these studies reveal an intimate structural and functional relationship between the nervous system and skin.


axon image


Research Lab

 

 

Audience

Free and open to the university community and the public

Hosted by: Rebecca Burdine, Molecular Biology

MolBio Events

Fri, Oct 31, 2014

Mon, Nov 03, 2014

Wed, Nov 05, 2014

Thu, Nov 06, 2014

Contact Us

Lewis Thomas Laboratory at Princeton University

119 Lewis Thomas Laboratory
Washington Road, Princeton, NJ  08544-1014

Need help? Contact us

Fax: (609) 258-3980
Website:  molbio.princeton.edu