Ry Young (Texas A & M University)

The event will start on: Wed, May 15, 2013 | 12:00 pm
Location: Lewis Thomas Lab, 003 | Washington Road

MolBio Seminar Series


youngRy Young
Texas A & M University

Fourth generation Texan, grew up in Dallas, undergraduate at CalTech and Rice (B.S., ’68) Doctoral work started in Biology at MIT, interrupted by military service in Navy, 1968-1971, finished at UT Dallas.  Thesis: Control of Ribosome Synthesis in E. coli; PhD supervisor Hans Bremer.  Post-doc at HMS under Mike Syvanen, 1975-78, studying mechanisms of gene transposition.  Assistant Professor 1978 Texas A&M College of Medicine, Dept. of Medical Biochemistry.  Moved to main campus Department of Biochemistry and Biophysics in 1985. Founded Center for Phage Technology in 2010.



Seminar Topic

Phage Lysis: do we have the hole story now?

Phage lysis of Gram-negative hosts is a precisely timed event involving the consecutive functions of three classes of proteins: holins, endolysins and spanins. The holins initiate the process by triggering to permeabilize the membrane at an allele-specific time, acting independently of any other host or phage protein, except in cases where a phage-encoded antiholin exerts an inhibitory effect.  The subsequent steps are peptidoglycan degradation and outer membrane disruption, effected by the endolysins and spanins, respectively.  Each functional class of lysis protein has at least two completely different types that appear to have evolved independently; moreover, holins and spanins are among the most diverse proteins in biology. Every step of the lysis process has been shown to involve membrane protein and bilayer dynamics.


young 2


Research Lab




Free and open to the university community and the public

Hosted by: Zemer Gitai, Molecular Biology

Upcoming Events

Wed, Sep 14, 2016

Tue, Sep 20, 2016

Wed, Sep 28, 2016

Contact Us

Lewis Thomas Laboratory at Princeton University

119 Lewis Thomas Laboratory
Washington Road, Princeton, NJ  08544-1014

Need help? Contact us

Fax: (609) 258-3980
Website:  molbio.princeton.edu